Bactoclav 625Mg

INDICATIONS

Amoxicillin potassium clavulanate is indicated in the treatment of infections caused by susceptible sterilized below. Lower Respiratory Tract Infections: Caused by b-lactamase-producing strains of Hemophilus influenzae and Moraxella (Branham Ella) catarrhalis. Otitis Media: Caused by b-lactamase producing strains of Hemophilus influenzae and Moraxella (Branham Ella) catarrhalis. Sinusitis: Caused by b-lactamase-producing strains of Hemophilus influenzae and Moraxella (Branham Ella) catarrhalis. Skin and Skin Structure Infections: Caused by b-lactamase-producing strains of Staphylococcus aureus, Escherichia coli and Klebsiella spp. Urinary Tract Infections: Caused by b-lactamase-producing strains of Escherichia coli, Klebsiella spp. and Enterobacter spp.

CONTRA-INDICATIONS

Amoxicillin; potassium clavulanate is contraindicated in patients with a history of allergic reactions to any penicillin. It is also contraindicated in patients with a previous history of Amoxicillin; potassium clavulanate-associated cholestatic jaundice/hepatic dysfunction. 

SIDE EFFECTS / ADVERSE REACTIONS

Amoxicillin: potassium clavulanate is generally well tolerated. The majority of side effects observed in clinical trials were of a mild and transient nature. The most frequently reported adverse effects were diarrhea/loose stools, nausea, skin rashes and urticaria, vomiting and vaginitis (1%). The overall incidence of side effects, and in particular diarrhea, increased with the higher recommended dose. Other less frequently reported reactions include abdominal discomfort. flatulence and headache. 

PRECAUTIONS / WARNINGS

The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur (usually involving Pseudomonas or Candida), the drug should be discontinued and/or appropriate therapy instituted. While amoxicillin: potassium clavulanate possesses the characteristic low toxicity of the penicillin group of antibiotics, periodic assessment of organ system functions, including renal. hepatic and hematopoietic function, is advisable during prolonged therapy. A high percentage of patients with mononucleosis who rare ampicillin develops an erythematous skin rash. Thus, ampicillin class antibiotics should not be administered to patients with mononucleosis. 

DRUG INTERACTIONS

Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use with amoxicillin; potassium clavulanate may result in increased and prolonged blood levels of amoxicillin. Amoxicillin: potassium clavulanate may reduce the efficacy of oral contraceptives. The possibilities of prolonged bleeding time in individuals receiving anti-coagulants concurrently should be borne in mind. 

OVER DOSAGE, SYMPTOMS & ANTIDOTE

Most patients have been asymptomatic following overdosage or have experienced primarily gastrointestinal symptoms including stomach and abdominal pain, vomiting, and diarrhea. Rash, hyperactivity, or drowsiness have also been observed in a small number of patients. In the case of overdosage, discontinue Amoxicillin; Potassium clavulanate, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication. an attempt at emesis or other means of removal of drug from the stomach may be performed. 

MICRO LABS LIMITED