Cilacar 10

INDICATIONS & USAGE

Cilnidipine is used for treatment of hypertension.

CONTRAINDICATIONS

Aortic stenosis, advanced. Hypersensitivity to Cilnidipine or other calcium channel antagonists.

WARNINGS & PRECAUTIONS

Angina, Chronic renal insufficiency, Congestive heart failure, Hypotension, Liver dysfunction, or elevated liver enzymes, Peripheral edema (confounding physical findings in congestive failure).

ADVERSE REACTIONS

Dizziness, headache, peripheral edema, flushing, rash and gingival hyperplasia are the most common adverse events seen with the dihydropyridine derivative calcium channel antagonists. Headache, Flushing was reported in 3.7 & 4.5% of 764 subjects receiving cilnidipine respectively.

DRUG INTERACTIONS

Cilnidipine can interact with aldesleukin, quinidine, phenytoin, rifampicin, erythromycin, other anti-hypertensive drugs and antipsychotic drugs. 

USE IN SPECIFIC POPULATIONS

Pregnancy: There are no human clinical or animal data concerning the safety of cilnidipine during pregnancy. Until data are available, administration of cilnidipine during pregnancy should be avoided. Lactation: Nursing mothers should consult a physician before taking Cilnidipine. Renal impairment: Dose adjustment is not needed in patients with impaired renal function. Cilnidipine at a dose of 10 mg once a day for 7 days in patients with impaired renal function caused no differences in the pharmacokinetic profile compared with that in patients with normal renal function. Hepatic impairment: Dosage recommendations have not been established in patients with mild to moderate hepatic impairment; therefore, dose selection should be cautious and should start at the lower end of the dosing range. Transient and generally clinically insignificant elevations in SGOT, SGPT, alkaline phosphatase, and serum bilirubin have been reported during calcium antagonist therapy in less than 1% of patients. 

OVERDOSAGE

None known

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