Melmet 850Mg

COMPOSITION

Melmet 500 Each film coated tablet contains Metformin Hydrochloride BP 500 mg. Melmet 850 Each film coated tablet contains Metformin Hydrochloride BP 850 mg. 

CONTRAINDICATIONS

Ketoacidosis; use of general anesthesia (suspend metformin on the morning of surgery and restart when renal function returns to baseline) Iodine-containing X-ray contrast media, intravascular administration of iodinated contrast agents can cause renal failure, which can increase the risk of lactic acidosis with metformin. Suspend metformin prior to the test; restart no earlier than 48 hours after the test if renal function has returned to baseline. Hepatic impairment: withdraw if tissue hypoxia likely. Renal impairment: Withdraw or interrupt treatment in those at risk of tissue hypoxia or sudden deterioration in renal function. 

SIDE EFFECTS / ADVERSE REACTIONS

anorexia nausea, vomiting, diarrhea (usually transient), abdominal pain, taste disturbance, rarely lactic acidosis (withdraw treatment), decreased vitamin-B12 absorption, erythema, pruritus and urticaria; hepatitis also reported. 

PRECAUTIONS AND WARNINGS

Determine renal function before treatment and at least annually (at least twice a year in patients with additional risk factors for renal impairment, or if deterioration suspected) Lactic acidosis: Use with caution in renal impairment increased risk of lactic acidosis; avoid in significant renal impairment. It recommends that the dose should be reviewed if eGFR less than 45 ml-/minute/1.73 m2 and to avoid if eGFR less than 30 mL/minute/1.73 m2. Withdraw or interrupt treatment in those at risk of tissue hypoxia or sudden deterioration in renal function, such as those with dehydration, severe infection, shock, sepsis acute heart failure, respiratory failure or hepatic impairment, or those who have recently had a myocardial infarction. 

OVERDOSAGE, SYMPTOMS & ANTIDOTE

Hypoglycemia has not been seen with metformin doses of up to 85g, although lactic acidosis has occurred in such circumstances. High overdose or concomitant risks of metformin may lead to lactic acidosis. Lactic acidosis is a medical emergency and must be treated in hospital. The most effective method to remove lactate and metformin is hemodialysis. 

MICRO LABS LIMITED