Loryt Oral Solution 60Ml

DESCRIPTION

Loratadine is a long-acting antihistamine having the chemical formula C22H23CIN2O2, the IUPAC name is ethyl 4-(8-chloro-5,6-dihydro-11H-benzo [5,6] cycloheptane [1,2-b] pyridin11-ylidene)-1-piperidinecarboxylate. 

INDICATIONS

Loratadine is indicated for the symptomatic relief of allergic rhinitis such as sneezing, runny nose, itching, ocular itching and burning, seasonal allergic rhinitis, perennial allergic rhinitis, symptoms of hay fever, symptoms associated with skin allergies including idiopathic chronic urticaria. 

PHARMACOKINETICS

Absorption: Loratadine is rapidly absorbed from the gastrointestinal tract after oral administration. Distribution: After oral administration of loratadine, its peak plasma concentration is attained in about I hour of time. Approximately 98% of loratadine is bound to plasma proteins. Loratadine and its metabolites have been detected in breast milk, but do not appear to cross the blood brain barrier to a significant extent. Metabolism: The major metabolic product of loratadine is desloratadine. Both loratadine and desloratadine have potent antihistaminic activity. Elimination: The mean elimination half-lives for loratadine and desloratadine are 8.4 and 28 hours, respectively. Most of the dose is excreted equally in the urine and faces. 

CONTRAINDICATION

Loratadine is contraindicated in patients who have severe hypersensitivity or idiosyncrasy to its components. 

WARNINGS

Caution may be required in patients with epilepsy. Loratadine should be used with caution in patients with urinary retention, glaucoma and pyloroduodenal obstruction. 

SIDE EFFECTS

Fatigue, nausea and headache were rarely reported. Incidence of sedation and antimuscarinic effects were low. 

DRUG INTERACTIONS

When administered concurrently with alcohol, Loratadine has no potentiating effect as measured by psychomotor performance studies. Cimetidine, Erythromycin and Ketoconazole can increase Loratadine plasma levels, but this is not commonly associated with clinically significant side effects. Interaction with other drugs has not been reported.

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