Mupiban Cream 5G

COMPOSITION

Mupirocin Calcium USP. Equivalent to Mupirocin (2.0% w/w). In a non-greasy base. 

INDICATION

Mupiban Cream is indicated for the topical treatment of secondarily infected traumatic lesions such as small lacerations, sutured wounds or abrasions (up to 10 cm in length or 100 cm2 in area), due to susceptible strains of Staphylococcus aureus and Streptococcus pyogenes. 

CONTRAINDICATION

Hypersensitivity to Mupirocin or any of the components of the formulation. 

WARNING & PRECAUTIONS

Should a possible sensitization reaction or severe local irritation occur with the use of Mupirocin Cream. treatment should be discontinued; the product should be washed off and appropriate therapy instituted. As with other antibacterial products, prolonged use may result in overgrowth of non-susceptible organisms. Pseudomembranous colitis has been reported with the use of antibiotics and may range in severity from mild to life-threatening. Therefore, it is important to consider its diagnosis in patients who develop diarrhea during or after antibiotic use. Although this is less likely to occur with topically applied mupirocin, if prolonged or significant diarrhea occurs or the patient experiences abdominal cramps, treatment should be discontinued immediately, and the patient investigated further. Mupirocin Cream formulation is not suitable for ophthalmic use and intranasal use. Avoid contact with the eyes. If contaminated, the eyes should be thoroughly irrigated with water until the cream residues have been removed. Mupirocin Cream contains cetyl alcohol and stearyl alcohol. These inactive ingredients may cause local skin reactions (e.g. contact dermatitis). 

PREGNANCY AND LACTATION

PREGNANCY: Manufacturer advises avoid unless potential benefit outweighs risk-no information available. LACTATION: No information available. 

UNDESIRABLE EFFECT

Burning sensation, local reactions, pruritus, rash and urticaria. RENAL IMPAIRMENT: Manufacturer advises caution when mupirocin ointment used in moderate or severe impairment because it contains macrogols (polyethylene glycol). 

PHARMACOLOGICAL ACTION

Mupirocin is an antibiotic which inhibits bacterial protein synthesis by binding to isoleucyl transfer RNA synthetase. It is primarily bacteriostatic at low concentrations, although it is usually bactericidal in the high concentrations achieved on the skin. 

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