Asclav Suspension 100Ml

COMPOSITION

Each 5ml of Asclav Dry Syrup contains Amoxicillin USP 125mg and 31.25mg. Clavulanic acid (as Potassium Clavulanate). 

INDICATIONS

Lower Respiratory Tract Infections: e.g. In acute or chronic bronchitis and pneumonia caused by beta-lactamase producing isolates of Hemophilus influenzae and Moraxella catarrhalis. Acute Bacterial Otitis Media: Caused by beta-lactamase producing isolates of H. influenzae and M. catarrhalis. Sinusitis: Caused by beta-lactamase producing isolates of H. influenzae and M. catarrhalis. Skin and Skin Structure Infections: e.g. Cellulitis, skin abscesses and infected wounds caused by beta-lactamase producing isolates of Staphylococcus aureus, Escherichia coli, and Klebsiella species. Urinary Tract Infections: e.g. Cystitis, urethritis, pyelonephritis which are caused by beta-lactamase producing isolates of E. coli, Klebsiella species and Enterobacter species. Other Infections: e.g. Severe dental infections and intra-abdominal infections. 

CONTRAINDICATION

Asclav is contraindicated in patients with a history of allergy to penicillin. Patients with a previous history of Amoxicillin/Clavulanic acid induced jaundice/hepatic dysfunction must avoid treatment with Asclav. 

PRECAUTIONS AND WARNINGS

Due to potential fatal anaphylactic reactions to penicillin, careful inquiry should be made prior to starting treatment with Asclav. Patients with infectious mononucleosis should avoid Asclav as the appearance of an erythematous rash has been reported in patients when treated with Amoxicillin. Superinfections such as pseudomembranous colitis have been reported with antibiotic use. Hence patients with prolonged diarrhea and abdominal Cramps should be investigated further.  levation in liver function test have been observed in patients receiving Amoxicillin/Clavulanic acid, hence Asclav should be used in caution with patients with hepatic impairment. Patients On treatment with anticoagulants would need to be monitored appropriately together with dose modification to ensure optimal level of anti-coagulation. 

SIDE EFFECTS

Amoxicillin/Clavulanic acid is generally Well tolerated and side effects are uncommon and mild. The following adverse effects have been observed: Gastro intestinal effects: Most commonly seen adverse effects are diarrhea. followed by nausea and vomiting and in very rare instances antibiotic associated colitis (see warning and precautions). Hepatobiliary effects: Less Commonly seen are moderate elevations in liver enzymes, with hepatitis and cholestatic jaundice seen very rarely. Skin and tissue disorders: Skin rash, pruritis are seen less commonly in patients treated with Amoxicillin/Clavulanic acid, while erythema multiforme, Stevens Johnsons syndrome, toxic epidermal necrolysis and exfoliative dermatitis are seen more rarely. Renal and urinary effects: Interstitial nephritis and crystalluria have been reported rarely. Hematological effects: In rare cases reversible leukopenia and thrombocytopenia can occur and very rarely prolongation of bleeding time and prothrombin time is seen. 

Astron Limited